Galectin 3 Binding Protein as a biomarker of choledochal cyst in children: A pilot study

Authors

  • Anil Kumar Ram
  • Yashwant Kumar
  • Prema Menon
  • Ravi Prakash Kanojia
  • Alka Bhatia
  • Ranjana Walker Minz

DOI:

https://doi.org/10.46831/jpas.v2i1.144

Keywords:

Galectin-3-binding protein, Choledochal cyst, Serological biomarker

Abstract

A choledochal cyst (CDC) is a rare congenital, single, or multiple cystic dilatations of the biliary tract encountered most commonly in infants and children. A sensitive and specific serological marker, if available, may add to its early recognition thereby avoiding the risk of complications frequently seen in these patients. We analyzed serum galectin-3-binding protein (Gal-3BP) levels in 21 children with CDC and 14 age-matched controls by the ELISA method. Serum Gal-3-BP levels were significantly raised in the patient group (36.6 ±25.2 ng/ml versus 7.0 ±4.3 ng/ml in controls; p <0.0001) and 95.2% of patients had Gal-3BP levels higher than the mean value in controls. Almost 67% of patients showed values ≥3 times of mean Gal-3BP level in controls (p <0.0001). Equal to 5 times or greater levels were seen in 43% of the patients (p = 0.0051). The study, therefore, suggests further evaluation of Gal-3BP as a potential biomarker for CDC and other biliary disorders.

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Author Biographies

Anil Kumar Ram

Departments of Immunopathology, Post Graduate Institute of Medical Education & Research, Chandigarh, India

Yashwant Kumar

Departments of Immunopathology, Post Graduate Institute of Medical Education & Research, Chandigarh, India

Prema Menon

Department of Pediatric Surgery, Post Graduate Institute of Medical Education & Research, Chandigarh, India

Ravi Prakash Kanojia

Department of Pediatric Surgery, Post Graduate Institute of Medical Education & Research, Chandigarh, India

Alka Bhatia

Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education & Research, Chandigarh, India

Ranjana Walker Minz

Departments of Immunopathology, Post Graduate Institute of Medical Education & Research, Chandigarh, India

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Published

2022-04-11

How to Cite

1.
Ram AK, Kumar Y, Menon P, Kanojia RP, Bhatia A, Minz RW. Galectin 3 Binding Protein as a biomarker of choledochal cyst in children: A pilot study. J Pediatr Adolesc Surg [Internet]. 2022Apr.11 [cited 2022Aug.7];2(1). Available from: http://jpedas.org/ojs/index.php/jpedas/article/view/jpas-144
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